Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID manustest
Sex MALE
Dominant hand LEFT
Test date and time 2022-02-04 09:06
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment .

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.66 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.66 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 0, 'TN': 0, 'TP': 42, 'FP': 30}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 10, 'TN': 8, 'TP': 32, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 2.768
timePerCircleCoV 0.174584
timePerCircleSlope -0.0558767
meanError 2.39872
tremorFreq 9.17969
tremorRelPower 20.3701
tremorGyroAmpMean 0.0289308
tremorGyroAmpSlope -0.0116425
tremorGyroAmpCoV 0.318059
tremorCoordAmpMean 0.188432
tremorCoordAmpSlope 0.0384822
tremorCoordAmpCoV 0.494412
tremorAccAmpMean 0.0244035
tremorAccAmpSlope 0.00163886
tremorAccAmpCoV 0.28995
tremorPcRelVar 0.54473
tremorPcX 0.660047
tremorPcY 0.751224

Circle Segment 1

Duration 3.52 s, Accuracy Estimate 2.26 (lower is better)

Circle Segment 2

Duration 3.12 s, Accuracy Estimate 2.153 (lower is better)

Circle Segment 3

Duration 3.36 s, Accuracy Estimate 2.241 (lower is better)

Circle Segment 4

Duration 3.0 s, Accuracy Estimate 2.034 (lower is better)

Circle Segment 5

Duration 2.72 s, Accuracy Estimate 2.114 (lower is better)

Circle Segment 6

Duration 2.68 s, Accuracy Estimate 2.144 (lower is better)

Circle Segment 7

Duration 2.68 s, Accuracy Estimate 2.02 (lower is better)

Circle Segment 8

Duration 2.32 s, Accuracy Estimate 2.315 (lower is better)

Circle Segment 9

Duration 2.16 s, Accuracy Estimate 2.464 (lower is better)

Circle Segment 10

Duration 2.12 s, Accuracy Estimate 4.242 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 8.204
timePerSpiralCoV 0.0817295
timePerSpiralSlope -0.0088944
meanError 2.21943
tremorFreq 6.93359
tremorRelPower 16.4275
tremorGyroAmpMean 0.0239198
tremorGyroAmpSlope 0.000804115
tremorGyroAmpCoV 0.32675
tremorCoordAmpMean 0.234549
tremorCoordAmpSlope -0.00178334
tremorCoordAmpCoV 0.442033
tremorAccAmpMean 0.03521
tremorAccAmpSlope 0.000426269
tremorAccAmpCoV 0.295898
tremorPcRelVar 0.616399
tremorPcX -0.982821
tremorPcY -0.184559

Spiral Segment 1

Duration 9.32 s, Accuracy Estimate 2.053 (lower is better)

Spiral Segment 2

Duration 8.76 s, Accuracy Estimate 2.415 (lower is better)

Spiral Segment 3

Duration 7.2 s, Accuracy Estimate 2.449 (lower is better)

Spiral Segment 4

Duration 7.76 s, Accuracy Estimate 2.088 (lower is better)

Spiral Segment 5

Duration 8.08 s, Accuracy Estimate 2.181 (lower is better)

Spiral Segment 6

Duration 8.16 s, Accuracy Estimate 2.187 (lower is better)

Spiral Segment 7

Duration 9.12 s, Accuracy Estimate 2.081 (lower is better)

Spiral Segment 8

Duration 7.88 s, Accuracy Estimate 2.091 (lower is better)

Spiral Segment 9

Duration 8.12 s, Accuracy Estimate 2.133 (lower is better)

Spiral Segment 10

Duration 7.64 s, Accuracy Estimate 2.516 (lower is better)

Elel

eDurationMean 0.260556
eDurationStd 0.0473598
eDurationStdnorm 0.181765
eDurationMedian 0.25
eDurationQuartdelta 0.07
eDurationQuartdeltanorm 0.28
eDurationKurt 2.58826
eDurationTrenddiff -0.035
eDurationTrendratio 0.872727
eWidthMean 7.01133
eWidthStd 1.71952
eWidthStdnorm 0.245249
eWidthMedian 7.254
eWidthQuartdelta 2.106
eWidthQuartdeltanorm 0.290323
eWidthKurt 2.81896
eWidthTrenddiff -0.468
eWidthTrendratio 0.935484
eHeightMean 13.312
eHeightStd 1.95087
eHeightStdnorm 0.14655
eHeightMedian 13.455
eHeightQuartdelta 3.24675
eHeightQuartdeltanorm 0.241304
eHeightKurt 1.80559
eHeightTrenddiff -1.404
eHeightTrendratio 0.902439
eAspectMean 0.529809
eAspectStd 0.124169
eAspectStdnorm 0.234366
eAspectMedian 0.526718
eAspectQuartdelta 0.209435
eAspectQuartdeltanorm 0.397623
eAspectKurt 2.61622
eAspectTrenddiff 0.0614232
eAspectTrendratio 1.13162
eSlantMean 0.0147277
eSlantStd 0.182391
eSlantStdnorm 12.3842
eSlantMedian -0.010101
eSlantQuartdelta 0.133477
eSlantQuartdeltanorm -13.2142
eSlantKurt 3.74504
eSlantTrenddiff -0.0343434
eRtopMean 0.755349
eRtopStd 0.0908696
eRtopStdnorm 0.120301
eRtopMedian 0.756757
eRtopQuartdelta 0.100219
eRtopQuartdeltanorm 0.132433
eRtopKurt 2.77561
eRtopTrenddiff -0.0197101
eRbotMean 0.765153
eRbotStd 0.273576
eRbotStdnorm 0.357544
eRbotMedian 0.767123
eRbotQuartdelta 0.275774
eRbotQuartdeltanorm 0.359491
eRbotKurt 2.78737
eRbotTrenddiff 0.0142698
eRrightMean 0.860306
eRrightStd 0.0623107
eRrightStdnorm 0.0724285
eRrightMedian 0.881481
eRrightQuartdelta 0.0830707
eRrightQuartdeltanorm 0.0942399
eRrightKurt 2.56281
eRrightTrenddiff -0.0543026
eRleftMean 0.384826
eRleftStd 0.100257
eRleftStdnorm 0.260524
eRleftMedian 0.4
eRleftQuartdelta 0.124327
eRleftQuartdeltanorm 0.310817
eRleftKurt 3.23478
eRleftTrenddiff -0.0277268
lDurationMean 0.3464
lDurationStd 0.0690338
lDurationStdnorm 0.199289
lDurationMedian 0.34
lDurationQuartdelta 0.075
lDurationQuartdeltanorm 0.220588
lDurationKurt 7.77144
lDurationTrenddiff -0.055
lDurationTrendratio 0.849315
lWidthMean 12.519
lWidthStd 2.8673
lWidthStdnorm 0.229036
lWidthMedian 12.753
lWidthQuartdelta 4.5045
lWidthQuartdeltanorm 0.353211
lWidthKurt 1.97442
lWidthTrenddiff 1.8135
lWidthTrendratio 1.15979
lHeightMean 34.4401
lHeightStd 3.26621
lHeightStdnorm 0.0948375
lHeightMedian 34.632
lHeightQuartdelta 4.1535
lHeightQuartdeltanorm 0.119932
lHeightKurt 2.76435
lHeightTrenddiff -2.925
lHeightTrendratio 0.917898
lAspectMean 0.363573
lAspectStd 0.0762259
lAspectStdnorm 0.209658
lAspectMedian 0.372611
lAspectQuartdelta 0.131762
lAspectQuartdeltanorm 0.353617
lAspectKurt 1.92453
lAspectTrenddiff 0.0783465
lAspectTrendratio 1.24914
lSlantMean 0.0921892
lSlantStd 0.0613402
lSlantStdnorm 0.665373
lSlantMedian 0.0794702
lSlantQuartdelta 0.0525206
lSlantQuartdeltanorm 0.660884
lSlantKurt 3.27818
lSlantTrenddiff 0.0314595
lRtopMean 0.871006
lRtopStd 0.0567146
lRtopStdnorm 0.065114
lRtopMedian 0.858333
lRtopQuartdelta 0.0929861
lRtopQuartdeltanorm 0.108333
lRtopKurt 2.04712
lRtopTrenddiff -0.00983766
lRbotMean 0.628522
lRbotStd 0.14995
lRbotStdnorm 0.238576
lRbotMedian 0.647887
lRbotQuartdelta 0.163408
lRbotQuartdeltanorm 0.252217
lRbotKurt 5.2609
lRbotTrenddiff -0.0866558
lRrightMean 0.94059
lRrightStd 0.0279789
lRrightStdnorm 0.0297461
lRrightMedian 0.931408
lRrightQuartdelta 0.0489193
lRrightQuartdeltanorm 0.0525218
lRrightKurt 1.79629
lRrightTrenddiff -0.00606555
lRleftMean 0.305983
lRleftStd 0.0601188
lRleftStdnorm 0.196478
lRleftMedian 0.313869
lRleftQuartdelta 0.0900681
lRleftQuartdeltanorm 0.286961
lRleftKurt 2.24477
lRleftTrenddiff -0.0212016

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

FITTS Short Modified

meanTouchScore 0.942032
sumTouchScores 39.5654
meanMovementTime 0.459634
numTouches 42
undershootPercentage 2.38095
overshootPercentage 11.9048

FITTS Long Modified

meanTouchScore 0.777363
sumTouchScores 17.102
meanMovementTime 0.614286
numTouches 22
undershootPercentage 4.54545
overshootPercentage 36.3636

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 7.272
timePerZigzagCoV 0.185247
timePerZigzagSlope -0.108911
meanError 3.52417
tremorFreq 6.64062
tremorRelPower 17.5122
tremorGyroAmpMean 0.0328515
tremorGyroAmpSlope 0.00679475
tremorGyroAmpCoV 0.189702
tremorCoordAmpMean 0.255821
tremorCoordAmpSlope 0.00973657
tremorCoordAmpCoV 0.304513
tremorAccAmpMean 0.0517666
tremorAccAmpSlope 0.0111452
tremorAccAmpCoV 0.228792
tremorPcRelVar 0.831522
tremorPcX 0.00606548
tremorPcY 0.999982

ZigZag Segment 1

Duration 9.44 s, Accuracy Estimate 3.254 (lower is better)

ZigZag Segment 2

Duration 7.68 s, Accuracy Estimate 3.131 (lower is better)

ZigZag Segment 3

Duration 6.72 s, Accuracy Estimate 3.261 (lower is better)

ZigZag Segment 4

Duration 6.4 s, Accuracy Estimate 3.714 (lower is better)

ZigZag Segment 5

Duration 6.12 s, Accuracy Estimate 4.261 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 5.736
timePerZigzagCoV 0.165802
timePerZigzagSlope -0.0801953
zigzagHeightMean 55.2717
zigzagHeightCoV 0.0551872
zigzagHeightSlope 0.0278948
meanError 0.0661087
tremorFreq 5.76172
tremorRelPower 25.3471
tremorGyroAmpMean 0.0707266
tremorGyroAmpSlope 0.0167235
tremorGyroAmpCoV 0.308748
tremorCoordAmpMean 0.640931
tremorCoordAmpSlope 0.0178753
tremorCoordAmpCoV 0.388081
tremorAccAmpMean 0.121916
tremorAccAmpSlope 0.00934202
tremorAccAmpCoV 0.173269
tremorPcRelVar 0.801503
tremorPcX 0.0634518
tremorPcY -0.997985

ZigZag Offset Segment 1

Duration 7.4 s, Accuracy Estimate 0.058 (lower is better)

ZigZag Offset Segment 2

Duration 5.44 s, Accuracy Estimate 0.065 (lower is better)

ZigZag Offset Segment 3

Duration 5.24 s, Accuracy Estimate 0.057 (lower is better)

ZigZag Offset Segment 4

Duration 5.56 s, Accuracy Estimate 0.059 (lower is better)

ZigZag Offset Segment 5

Duration 5.04 s, Accuracy Estimate 0.091 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.8}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.66}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.8448345568908902}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Healthy’, ‘BM_HC_Sep22_score’: 0.13290076108164328}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4877726555217643}